Invention Grant
- Patent Title: Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration
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Application No.: US15972489Application Date: 2018-05-07
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Publication No.: US11918650B2Publication Date: 2024-03-05
- Inventor: Jeff Abel , Lingwen Cui , Devrishi Goswami , Joon Huh , Bharadwaj Jagannathan , Sekhar Kanapuram , Arnold McAuley , Michael Schneider , Ananthakrishnan G. Sethuraman , Michael Treuheit , Jun Zhang
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agency: MARSHALL, GERSTEIN & BORUN LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; A61K9/00 ; A61K9/08 ; A61K9/19 ; A61K47/10 ; A61K47/12 ; A61K47/14 ; A61K47/18 ; A61K47/24 ; A61K47/26 ; C07K16/28 ; C07K16/46 ; A61J1/05 ; A61J1/10 ; A61K39/00
Abstract:
The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 μg/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.
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