Invention Grant
- Patent Title: Bisphenol derivatives and their use as androgen receptor activity modulators
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Application No.: US17404589Application Date: 2021-08-17
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Publication No.: US11919874B2Publication Date: 2024-03-05
- Inventor: Raymond J. Andersen , Marianne Dorothy Sadar , Kunzhong Jian , Nasrin R. Mawji , Jun Wang , Carmen Adriana Banuelos , Yu-Chi Yang
- Applicant: The University of British Columbia , Provincial Health Services Authority
- Applicant Address: CA Vancouver
- Assignee: The University of British Columbia,Provincial Health Services Authority
- Current Assignee: The University of British Columbia,Provincial Health Services Authority
- Current Assignee Address: CA Vancouver; CA Vancouver
- Agency: COOLEY LLP
- The original application number of the division: US16848061 2020.04.14
- Main IPC: C07D295/088
- IPC: C07D295/088 ; A61K31/09 ; A61K31/10 ; A61K31/145 ; A61K31/4164 ; A61K31/5375 ; A61K45/06 ; C07C43/23 ; C07C69/28 ; C07C233/18 ; C07C311/04 ; C07C311/51 ; C07C317/18 ; C07C317/22 ; C07C317/28 ; C07D233/60
Abstract:
Compounds having a structure of Formula I:
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, R11a, R11b, R11c, R11d, and X, are as defined herein, are provided. Uses of such compounds for modulating androgen receptor activity, imaging diagnostics in cancer and therapeutics, and methods for treatment of subjects in need thereof, including prostate cancer are also provided.
Public/Granted literature
- US20210387957A1 BISPHENOL DERIVATIVES AND THEIR USE AS ANDROGEN RECEPTOR ACTIVITY MODULATORS Public/Granted day:2021-12-16
Information query
