Invention Grant
- Patent Title: 4-phenylpiperidines, their preparation and use
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Application No.: US17320158Application Date: 2021-05-13
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Publication No.: US11919913B2Publication Date: 2024-03-05
- Inventor: Konstantin Petrukhin , Christopher Cioffi , Graham Johnson , Nicoleta Dobri , Emily Freeman , Ping Chen , Michael Conlon , Lei Zhu
- Applicant: The Trustees of Columbia University in the City of New York
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agent Gary J. Gershik
- The original application number of the division: US16151019 2018.10.03
- Main IPC: C07D498/04
- IPC: C07D498/04 ; A61K31/437 ; A61K31/4375 ; A61K31/454 ; A61K31/4545 ; A61K31/497 ; A61K31/501 ; A61K31/5025 ; A61K31/506 ; A61P27/02 ; C07D401/06 ; C07D405/14 ; C07D409/06 ; C07D471/04 ; C07D487/04 ; C07D491/052 ; C07D495/04

Abstract:
The present invention provides a compound having the structure:
wherein
R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl;
R4 is H, OH, or halogen;
B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole,
wherein the heterobicycle is other than chloro substituted indole; and
the pyrazole, when substituted, is substituted with other than trifluoromethyl,
or a pharmaceutically acceptable salt thereof.
wherein
R1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl;
R4 is H, OH, or halogen;
B is a substituted or unsubstituted heterobicycle, pyridazine, pyrazole, pyrazine, thiadiazole, or triazole,
wherein the heterobicycle is other than chloro substituted indole; and
the pyrazole, when substituted, is substituted with other than trifluoromethyl,
or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20210363155A1 4-PHENYLPIPERIDINES, THEIR PREPARATION AND USE Public/Granted day:2021-11-25
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