A heat exchange tube, a heat exchanger, and a manufacturing method for the heat exchange tube are provided. The heat exchange tube includes a tube wall and an outer fin, the tube wall is folded into a tube body, the tube body is provided with an inner fin therein, and the inner fin divides an inner chamber of the tube body into a plurality of flow channels. The outer fin is arranged outside the tube body. The outer fin is folded from a same plate with at least one of the tube wall and the inner fin.