The disclosure relates to methods, devices, systems, and computer storage medium for performing medical image segmentation. The method includes: The method includes: obtaining, by a device, a first medical image and a second medical image with a labeled region; performing, by the device, feature extraction on the first medical image and the second medical image respectively, to obtain first feature information of the first medical image and second feature information of the second medical image; obtaining, by the device, optical flow motion information from the second medical image to the first medical image according to the first feature information and the second feature information; and segmenting, by the device, the first medical image according to the optical flow motion information and the labeled region, to obtain a segmentation result of the first medical image.