The present disclosure provides a method and an apparatus for noise reduction, and a headset. The method of noise reduction includes: acquiring a first reference noise signal; acquiring an initial direction of desired speech in response to a trigger signal; acquiring a real-time direction of desired speech based on a real-time orientation of the headset and the initial direction of desired speech, the real-time orientation being obtained by orientation tracking for the headset; filtering out a desired speech signal from the first reference noise signal to acquire an undesired noise signal, the desired speech signal being extracted in the real-time direction of desired speech; and filtering the undesired noise signal to output an inverse noise signal for speaker playback. Thus, using the method of noise reduction, not only the undesired noise in the ambient noise can be cancelled, but also the desired speech signal can be retained.