A weightlifting shoe has a bottom sole, a midsole comprising a thermoplastic polyurethane (TPU), and one or more panels attached to one or both of the midsole and the bottom sole to define an enclosure for a person's foot. The midsole may be disposed above at least a portion of the bottom sole and may have a decreasing thickness in a direction from a rear region of the bottom sole toward a front region of the bottom sole opposite the rear region. The enclosure may have an axis defined between opposing front and rear points on the enclosure at a longest part thereof and may have a width defined perpendicular to the axis. The width of the enclosure may have a maximum value at a position along the axis that is more than 70% of the way from the rear point to the front point.