Small molecule myristate inhibitors of Bcr-abl and methods of use

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US11932646B2 Small molecule myristate inhibitors of Bcr-abl and methods of use 有权

Patent Title: Small molecule myristate inhibitors of Bcr-abl and methods of use
Application No.: US17574132

Application Date: 2022-01-12
Publication No.: US11932646B2

Publication Date: 2024-03-19
Inventor: Nathanael S. Gray , Jianming Zhang , Barun Okram , Xianming Deng , Jae Won Chang , Amy Wojciechowski
Applicant: Dana-Farber Cancer Institute, Inc. , The Scripps Research Institute
Applicant Address: US MA Boston
Assignee: THE SCRIPPS RESEARCH INSTITUTE,DANA-FARBER CANCER INSTITUTE, INC.
Current Assignee: THE SCRIPPS RESEARCH INSTITUTE,DANA-FARBER CANCER INSTITUTE, INC.
Current Assignee Address: US CA La Jolla; US MA Boston
Agency: Crowell & Moring LLP
Agent Yuezhong Feng
The original application number of the division: US16170921 2018.10.25
Main IPC: C07D239/94
IPC: C07D239/94 ; A61K31/517 ; A61K31/519 ; A61K31/52 ; A61K31/5377 ; A61K31/7076 ; A61K45/06 ; A61P9/00 ; A61P17/00 ; A61P19/00 ; A61P35/00 ; A61P35/02 ; C07D239/42 ; C07D403/04 ; C07D403/06 ; C07D403/12 ; C07D417/04 ; C07D471/04 ; C07D473/34 ; C07D487/04 ; C07D495/04 ; C07H19/16

Abstract:

The present disclosure provides novel heteroaryl compounds of formula (VII). Such compounds are useful for the treatment of cancers.

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