Invention Grant
- Patent Title: Anti-ROR1 antibody and ROR1-targeting engineered cells
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Application No.: US18321655Application Date: 2023-05-22
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Publication No.: US11932703B2Publication Date: 2024-03-19
- Inventor: Vita Golubovskaya , Lijun Wu
- Applicant: Caribou Biosciences, Inc.
- Applicant Address: US CA Berkeley
- Assignee: Caribou Biosciences, Inc.
- Current Assignee: Caribou Biosciences, Inc.
- Current Assignee Address: US CA Berkeley
- Agent Barbara G. McClung; Olga Zimmerman
- Main IPC: C07K16/40
- IPC: C07K16/40 ; C07K14/725
Abstract:
The present invention is directed to a monoclonal mouse or humanized ROR1 antibody, or a single-chain variable fragment (scFv). The present invention is also directed to a mouse or humanized ROR1 chimeric antigen receptor (CAR) comprising from N-terminus to C-terminus: (i) a single-chain variable fragment (scFv) of the present invention, (ii) a transmembrane domain, (iii) at least one co-stimulatory domains, and (iv) an activating domain.
Public/Granted literature
- US20230383009A1 ANTI-ROR1 ANTIBODY AND ROR1-TARGETING ENGINEERED CELLS Public/Granted day:2023-11-30
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