- Patent Title: Methylation classifier for detection of HPV-induced invasive cancers, nonHPV-induced gynaecological and anogenital cancers and their high-grade precursor lesions
-
Application No.: US16491182Application Date: 2018-03-09
-
Publication No.: US11932909B2Publication Date: 2024-03-19
- Inventor: Christophorus Joannes Lambertus Maria Meijer , Renske Daniëla Maria Steenbergen , Petrus Josephus Ferdinandus Snijders , Daniëlle Anne Marie Heideman
- Applicant: SELF-SCREEN B.V.
- Applicant Address: NL Amsterdam
- Assignee: SELF-SCREEN B.V.
- Current Assignee: SELF-SCREEN B.V.
- Current Assignee Address: NL Amsterdam
- Agency: Leason Ellis LLP
- Priority: EP 160346 2017.03.10
- International Application: PCT/NL2018/050143 2018.03.09
- International Announcement: WO2018/164577A 2018.09.13
- Date entered country: 2019-09-05
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/04 ; C12Q1/6886
Abstract:
The invention relates to method for detecting HPV-induced high-grade precancerous lesions, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers, said method comprising detection of a methylation classifier consisting of the genes LHX8, ASCL1 and ST6GALNAC5 and their regulatory sequence in a cell whereby such hypermethylation indicates the presence of HPV-induced precursor lesions with invasive potential, HPV-induced invasive cancers and nonHPV-induced gynaecological and anogenital cancers. The invention further comprises the use of the methylation classifier consisting of genes LHX8, ASCL1 and ST6GALNAC5 and their regulatory sequence in such a method and a test kit for the detection of LHX8. ASCL1 and/or ST6GALNAC5 methylation.
Public/Granted literature
Information query
