The presently disclosed adjustable slide knob addresses the ‘Backing-Off’ problem present with various conventional nuts. The adjustable slide knobs can be quickly positioned along a threaded rod by applying pressure to an exposed surface of a partially threaded nut. When the knob is placed against a work surface and the user releases pressure from the partially threaded nut, the thread pattern on the partially threaded nut meshes with the matching thread pattern on the threaded rod. The device can then be twisted, which will translate the device along the threaded rod, to apply a larger load to the work surface. The threaded rod may include one or more key-ways shaped to allow a locking tab housed within the knob to stop the device from freely disengaging the threaded rod to protect a user from potential injury caused by the fastener unexpectedly backing off and disengaging.