Surgical systems are provided. In one exemplary embodiment, a surgical system includes first and second port devices, that are each configured to be at least partially disposed within a body. The first port device includes a first housing defining a first plurality of ports each configured to allow a respective instrument of a first set of instruments to be inserted therethrough. The first port device is configured to interact with at least one respective instrument that is inserted through its respective port. The second port device is configured to interact with at least one respective instrument that is inserted through its respective port. The first and second port devices are each configured to allow at least a portion of the first set of instruments and at least a portion of the second set of instruments to work cooperatively together. Methods for using the same are also provided.