Invention Grant
- Patent Title: Precision control of large-scale green synthesis of biodegradable gold nanodandelions as potential radiotheranostics
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Application No.: US17286439Application Date: 2018-10-18
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Publication No.: US11938546B2Publication Date: 2024-03-26
- Inventor: Leu-Wei Lo , Yao-Chen Chuang
- Applicant: NATIONAL HEALTH RESEARCH INSTITUTES , Leu-Wei Lo
- Applicant Address: TW Zhunan Town
- Assignee: NATIONAL HEALTH RESEARCH INSTITUTES
- Current Assignee: NATIONAL HEALTH RESEARCH INSTITUTES
- Current Assignee Address: TW Zhunan Town
- Agency: Muncy, Geissler, Olds & Lowe, P.C.
- International Application: PCT/US2018/056540 2018.10.18
- International Announcement: WO2020/081088A 2020.04.23
- Date entered country: 2021-04-16
- Main IPC: B22F9/24
- IPC: B22F9/24 ; A61K9/14 ; A61K41/00 ; B22F1/054 ; B82Y5/00 ; B82Y40/00

Abstract:
The present invention relates to a new type of metabolizable flower-like gold nanodandelion (GND), which possesses features: (1) large scale green synthesis with high monodispersity and a circa 100% yield; (2) cellular/physiological degradability; (3) precision control of the shape, petal number and size; (4) highly efficient radiotheranostics encompassing better enhanced CT contrast and pronounced x-ray induced ROS generation than conventional spherical AuNP.
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