The present invention discloses a three-dimensional printing device, comprising: a chassis, a light source and a controller, wherein a liquid storage tank is arranged in the middle of the chassis, an anti-sticking element is arranged on the inner wall of the liquid storage tank, and the liquid storage tank is used for holding polymerizable liquid; and further comprising: a base which is adapted to the liquid storage tank in a para-position way, wherein the base is connected with a driving device, and the light source is matched with the bottom of the base. By using the anti-sticking element as a covering part for the liquid storage tank, the forming part formed by curing the polymerizable liquid can lose contact with the anti-sticking element quickly and efficiently, so as to carry out further formation and processing operations. In this way, the whole three-dimensional printing process is more rapid and efficient. Meanwhile, the damage to the structure of the product or component caused by excessive adhesion during the separation of the formed product from the device component is effectively avoided, and therefore the processing effect of the product and the stable operation of the device component are ensured. The present invention further discloses a three-dimensional printing method using the above three-dimensional printing device.