Variant adeno-associated viruses and methods of using

Invention Grant

US11939355B2 Variant adeno-associated viruses and methods of using 有权

Patent Title: Variant adeno-associated viruses and methods of using
Application No.: US17209336

Application Date: 2021-03-23
Publication No.: US11939355B2

Publication Date: 2024-03-26
Inventor: Joshua Dudman , Adam Hantman , Bum-Yeol Hwang , Alla Karpova , Loren Looger , Kimberly Ritola , David Schaffer , Dougal Gowanlock Robinson Tervo , Sarada Viswanathan
Applicant: Howard Hughes Medical Institute , The Regents of the University of California
Applicant Address: US MD Chevy Chase
Assignee: Howard Hughes Medical Institute
Current Assignee: Howard Hughes Medical Institute
Current Assignee Address: US MD Chevy Chase
Agency: Fish & Richardson P.C.
Main IPC: C12N7/00
IPC: C12N7/00 ; C07K14/005 ; C07K14/015 ; C12N15/86 ; C40B30/06 ; C40B40/08 ; A61K48/00

Abstract:

The present disclosure provides AAV variants that exhibit a preference for retrograde movement in neurons and methods of using such variants.

Public/Granted literature

Information query

Espacenet

IPC分类:

C	化学；冶金
C12	生物化学；啤酒；烈性酒；果汁酒；醋；微生物学；酶学；突变或遗传工程
C12N	微生物或酶；其组合物；繁殖、保藏或维持微生物；变异或遗传工程；培养基（微生物学的试验介质入C12Q1/00）。
C12N7/00	病毒，如噬菌体；其组合物；其制备或纯化（含有病毒药物的制备入A61K35/76；药用病毒抗原或抗体组合物的制备，如病毒菌苗入A61K39/00）