Invention Grant
- Patent Title: Pan-ebola virus neutralizing human antibodies and methods of use therefor
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Application No.: US17259263Application Date: 2019-07-11
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Publication No.: US11939370B2Publication Date: 2024-03-26
- Inventor: James E. Crowe, Jr. , Pavlo Gilchuk , Alexander Bukreyev
- Applicant: VANDERBILT UNIVERSITY , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Applicant Address: US TN Nashville
- Assignee: VANDERBILT UNIVERSITY,BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee: VANDERBILT UNIVERSITY,BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee Address: US TN Nashville; US TX Austin
- Agency: Parker Highlander PLLC
- International Application: PCT/US2019/041349 2019.07.11
- International Announcement: WO2020/014443A 2020.01.16
- Date entered country: 2021-01-11
- Main IPC: C07K16/10
- IPC: C07K16/10 ; A61K39/00 ; A61P31/14 ; G01N33/569

Abstract:
The present disclosure is directed to human antibodies binding to and neutralizing ebolavirus and methods for use thereof. A further embodiment involves a monoclonal antibody, wherein the antibody or antibody fragment is characterized by clone-paired heavy and light chain CDR sequences. In yet another embodiment, there is provided a hybridoma or engineered cell encoding an antibody or antibody fragment. An additional embodiment comprises a vaccine formulation comprising one or more antibodies or antibody fragments characterized by clone-paired heavy and light chain CDR sequences. In still a further embodiment, there is provided a method of protecting the health of a placenta and/or fetus of a pregnant a subject infected with or at risk of infection with ebolavirus comprising delivering to said subject the antibody or antibody fragment.
Public/Granted literature
- US20210403538A1 PAN-EBOLAVIRUS NEUTRALIZING HUMAN ANTIBODIES AND METHODS OF USE THEREFOR Public/Granted day:2021-12-30
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