An opening and closing device for a vehicle sliding door, including: a latch; a ratchet; a power closer; a closing lever configured to rotate the latch in a closing direction from a half latched position to a fully latched position, by being rotated by motor power of the power closer; a cancel lever configured to shift between: a coupling position where rotation of the closing lever is transmitted to the latch; and a cancel position where rotation of the closing lever is not transmitted to the latch; and a first lever and a second lever configured to move the cancel lever from the coupling position to the cancel position by operation of an operating handle of a sliding door, wherein the cancel lever includes a non-flat reinforced contacting part to which the first lever and the second lever are independently configured to brought into contact.