A therapy device comprises a shaft extending between proximal and distal portions, a surgical instrument located at the distal portion, a handpiece located at the proximal portion, a treatment end located at the distal end of the surgical instrument that can apply photodynamic therapy (PDT). The treatment end includes an applicator to apply a photosensitizer to a surface of a target tissue and a light emitter that can emit generated phototherapeutic light to activate the photosensitizer to ablate target tissue. A method for providing PDT to the target tissue includes inserting the therapy device into the patent, applying the photosensitizer and phototherapeutic light to a surface of the target tissue, and removing the device from the patient.