Techniques to facilitate adaptive optimization and control of flotation cell processing are disclosed herein. In at least one implementation, a computing system receives a plurality of flotation cell process variables associated with a flotation cell process. The flotation cell process variables are fed into a machine learning model associated with the flotation cell process to determine improved settings for the flotation cell process. The improved settings for the flotation cell process are provided to an industrial controller that controls at least one aspect of the flotation cell process to improve the flotation cell process.