Upon detecting a mobile object approaching a target region, a target speed profile for a vehicle, a position and a speed for the vehicle, and a position and a speed for the mobile object are input to a first neural network that outputs an entry probability distribution of predicted entry times at which the mobile object will enter the target region. The target speed profile, the position and the speed for the vehicle, the position and the speed for the mobile object, and a predicted entry time at which the mobile object entered the target region are input to a second neural network that outputs an exit probability distribution of predicted exit times at which the mobile object will exit the target region. An optimized speed profile is determined based on the entry and exit probability distributions by executing a model predictive control algorithm in a rolling horizon. A vehicle is operated based on the optimized speed profile.