Invention Grant
- Patent Title: 1-cyano-pyrrolidine derivatives as dub inhibitors
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Application No.: US17674943Application Date: 2022-02-18
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Publication No.: US11945797B2Publication Date: 2024-04-02
- Inventor: Alison Jones , Mark Ian Kemp , Martin Lee Stockley , Michael David Woodrow
- Applicant: MISSION THERAPEUTICS LIMITED
- Applicant Address: GB Cambridge
- Assignee: Mission Therapeutics Limited
- Current Assignee: Mission Therapeutics Limited
- Current Assignee Address: GB Cambridge
- Priority: GB 05059 2016.03.24 GB 00839 2017.01.18
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D403/04 ; C07D403/14 ; C07D413/04 ; C07D413/14 ; C07D417/14

Abstract:
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30). The novel compounds have formula (I): (Formula (I)) or are pharmaceutically acceptable salts thereof, wherein: R1a, R1b, R1c, R1d, R1e and R1f each independently represent hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C3-C4 cycloalkyl, or R1b and R1c together form an optionally substituted C3-C6 cycloalkyl ring, or R1d and R1e together form an optionally substituted C3-C6 cycloalkyl ring; R2 represents hydrogen or optionally substituted C1-C6 alkyl; A represents an optionally further substituted 5 to 10 membered monocyclic or bicyclic heteroaryl, heterocyclyl or aryl ring; L represents a covalent bond or linker; B represents an optionally substituted 3 to 10 membered monocyclic or bicyclic heterocyclyl, heteroaryl, cycloalkyl or aryl ring; and when -A-L-B is at position x attachment to A is via a carbon ring atom of A, and either: A cannot be triazolopyridazinyl, triazolopyridinyl, imidazotriazinyl, imidazopyrazinyl or pyrrolopyrimidinyl; or B cannot be substituted with phenoxyl; or B cannot be cyclopentyl when L is an oxygen atom.
Public/Granted literature
- US20220177451A1 1-CYANO-PYRROLIDINE DERIVATIVES AS DUB INHIBITORS Public/Granted day:2022-06-09
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