Invention Grant
- Patent Title: Modulators of RAS GTPase
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Application No.: US17260711Application Date: 2019-08-06
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Publication No.: US11945803B2Publication Date: 2024-04-02
- Inventor: Annie L. Lennek , Stephen D. Yanofsky , Brian D. Frenzel , Solomon B. Ungashe , William A. Garland , Philip Liaw
- Applicant: Tosk, Inc.
- Applicant Address: US CA Mountain View
- Assignee: Tosk, Inc.
- Current Assignee: Tosk, Inc.
- Current Assignee Address: US CA Mountain View
- Agency: Bozicevic, Field & Francis LLP
- Agent James J. Diehl; Bret E. Field
- International Application: PCT/US2019/045315 2019.08.06
- International Announcement: WO2020/033413A 2020.02.13
- Date entered country: 2021-01-15
- Main IPC: C07D403/14
- IPC: C07D403/14 ; C07D413/12

Abstract:
RAS modulating compounds and methods of using the same are provided. The compounds find use in modulating the activity of a target RAS in a sample. The target RAS can be a mutant RAS that is implicated in a disease of interest. In some cases, the subject compounds can inhibit the growth of cancer cells whose progression is driven by kRAS or a mutated kRAS. Methods of treating a subject for a RAS driven disease including administering a therapeutically effective amount of the subject compound are provided. Also provided are pharmaceutical compositions and kits which include the subject compounds.
Public/Granted literature
- US20210261532A1 Modulators of RAS GTPase Public/Granted day:2021-08-26
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