Invention Grant
- Patent Title: Depletion of light chain mispaired antibody variants by hydrophobic interaction chromatography
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Application No.: US16955776Application Date: 2018-12-20
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Publication No.: US11945839B2Publication Date: 2024-04-02
- Inventor: Thomas Von Hirschheydt , Petra Rueger , Birgit Weydanz , Hubert Hertenberger
- Applicant: Hoffmann-La Roche Inc.
- Applicant Address: US NJ Little Falls
- Assignee: Hoffmann-La Roche Inc.
- Current Assignee: Hoffmann-La Roche Inc.
- Current Assignee Address: US NJ Little Falls
- Agency: Grimes & Yvon LLP
- Priority: EP 210376 2017.12.22
- International Application: PCT/EP2018/086059 2018.12.20
- International Announcement: WO2019/122054A 2019.06.27
- Date entered country: 2020-06-19
- Main IPC: C07K1/20
- IPC: C07K1/20 ; C07K16/28 ; C07K16/40
Abstract:
The present invention relates to methods for separating multispecific CrossMab antibodies from light chain mispaired variants thereof in a solution comprising CrossMab bispecific antibodies and mispaired antibody variants thereof by hydrophobic interaction chromatography.
Public/Granted literature
- US20200369719A1 Depletion of Light Chain Mispaired Antibody Variants By Hydrophobic Interaction Chromatography Public/Granted day:2020-11-26
Information query
