Invention Grant
- Patent Title: Compositions and methods for regulation of chronic toxoplasma infection
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Application No.: US17595894Application Date: 2020-05-30
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Publication No.: US11945845B2Publication Date: 2024-04-02
- Inventor: Ben Waldman , Sebastian Lourido
- Applicant: Whitehead Institute for Biomedical Research
- Applicant Address: US MA Cambridge
- Assignee: Whitehead Institute for Biomedical Research
- Current Assignee: Whitehead Institute for Biomedical Research
- Current Assignee Address: US MA Cambridge
- Agency: Hamilton, Brook, Smith & Reynolds, P.C.
- International Application: PCT/US2020/035461 2020.05.30
- International Announcement: WO2020/243675A 2020.12.03
- Date entered country: 2021-11-29
- Main IPC: A61K39/002
- IPC: A61K39/002 ; A61P33/02 ; A61P37/04 ; C07K14/45 ; C12N1/10 ; C12N15/74 ; A61K39/00
Abstract:
The present disclosure provides genetically altered protozoan parasites comprising a mutation in a bradyzoite formation deficient 1 (BFD1) gene, wherein the mutation inhibits differentiation of the parasite into a bradyzoite. The genetically altered protozoan parasites can be utilized in vaccine compositions and in methods of treating apicomplexan parasite infection.
Public/Granted literature
- US20220235101A1 Compositions and Methods for Regulation of Chronic Toxoplasma Infection Public/Granted day:2022-07-28
Information query
