Invention Grant
- Patent Title: Genetically modified probiotics for oral delivery of renin-angiotensin related therapeutic proteins and peptides
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Application No.: US17839815Application Date: 2022-06-14
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Publication No.: US11945853B2Publication Date: 2024-04-02
- Inventor: Qiuhong Li , Mohan Raizada
- Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
- Applicant Address: US FL Gainesville
- Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
- Current Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
- Current Assignee Address: US FL Gainesville
- Agency: WOLTER, VAN DYKE, DAVIS, PLLC
- Agent Timothy H. Van Dyke
- The original application number of the division: US16333044
- Main IPC: C07K14/575
- IPC: C07K14/575 ; A61K35/00 ; A61K35/74 ; A61K35/741 ; A61K35/747 ; A61K45/06 ; A61K48/00 ; A61P3/00 ; A61P3/10 ; A61P9/12 ; A61P27/02 ; A61P29/00 ; C07K7/14 ; C07K14/195 ; C07K14/28 ; C07K14/47 ; C07K19/00 ; C12N1/00 ; C12N9/48
Abstract:
Provided herein are polynucleic acids and expression vectors for the expression and secretion of angiotensin peptide fragments (e.g., angiotensin-(1-7)) in probiotic bacteria. Provided herein are also probiotic compositions that enable efficient, cost-effective and patient friendly oral therapeutics for treating diverse pathological conditions that involve the renin-angiotensin system (RAS), e.g., pulmonary hypertension, diabetes, diabetic complications, cardiovascular diseases, and ocular inflammatory and neurodegenerative diseases.
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