Invention Grant
- Patent Title: Transfected T-cells and T-cell receptors for use in immunotherapy against cancers
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Application No.: US17125922Application Date: 2020-12-17
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Publication No.: US11945854B2Publication Date: 2024-04-02
- Inventor: Dominik Maurer , Sebastian Bunk , Leonie Alten
- Applicant: IMMATICS BIOTECHNOLOGIES GMBH
- Applicant Address: DE Tuebingen
- Assignee: IMMATICS BIOTECHNOLOGIES GMBH
- Current Assignee: IMMATICS BIOTECHNOLOGIES GMBH
- Current Assignee Address: DE Tuebingen
- Agency: McBee, Moore & Vanik IP, LLC
- Priority: GB 04492 2016.03.16
- Main IPC: C07K14/725
- IPC: C07K14/725 ; A61K35/12 ; A61K35/17 ; A61K35/66 ; C07K14/435 ; C12N15/09 ; C12N15/10 ; A61K38/00

Abstract:
Disclosed are T-cell receptors (TCRs) binding to tumor-associated antigens (TAAs) for targeting cancer cells, T-cells expressing same, methods for producing same, and methods for treating cancers using same. Disclosed are TCRs and their variants that bind to HLA class I or II molecules with a peptide, such as MAG-003 have the amino acid sequence of KVLEHVVRV (SEQ ID NO:1). The description further relates to peptides, proteins, nucleic acids, cells for use in immunotherapeutic methods, the immunotherapy of cancer, and tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T-cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
Public/Granted literature
- US20210101956A1 TRANSFECTED T-CELLS AND T-CELL RECEPTORS FOR USE IN IMMUNOTHERAPY AGAINST CANCERS Public/Granted day:2021-04-08
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