Invention Grant
- Patent Title: Recombinant polypeptides comprising modified MHC class II DRa1 domains and methods of use
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Application No.: US17282455Application Date: 2019-10-04
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Publication No.: US11945855B2Publication Date: 2024-04-02
- Inventor: Roberto Meza-Romero , Arthur A. Vandenbark , Halina Offner
- Applicant: Oregon Health & Science University , The United States Government as represented by the Department of Veterans Affairs
- Applicant Address: US OR Portland
- Assignee: Oregon Health & Science University,The United States Government as represented by the Department of Veterans Affairs
- Current Assignee: Oregon Health & Science University,The United States Government as represented by the Department of Veterans Affairs
- Current Assignee Address: US OR Portland; US DC Washington
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2019/054850 2019.10.04
- International Announcement: WO2020/072992A 2020.04.09
- Date entered country: 2021-04-02
- Main IPC: C07K14/74
- IPC: C07K14/74 ; A61K39/00 ; A61P37/06
Abstract:
Recombinant polypeptides comprising a modified DRα1 domain are provided. In some embodiments, the polypeptides include the modified DRα1 domain, an antigenic peptide, and optionally a linker sequence. Pharmaceutical compositions comprising the recombinant polypeptides, methods of treating inflammatory disease using said recombinant polypeptides or pharmaceutical compositions, and expression constructs comprising nucleic acids that encode the recombinant polypeptides are also provided.
Public/Granted literature
- US20210380660A1 RECOMBINANT POLYPEPTIDES COMPRISING MODIFIED MHC CLASS II DRa1 DOMAINS AND METHODS OF USE Public/Granted day:2021-12-09
Information query
