Invention Grant
- Patent Title: Multispecific antigens binding fragments and multispecific antibodies
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Application No.: US16996510Application Date: 2020-08-18
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Publication No.: US11945879B2Publication Date: 2024-04-02
- Inventor: Jean Kadouche , Jean-Pierre Mach , Olivier Michielin , Vincent Zoete , Justyna Iwaszkiewicz , Martine Cerutti , Sylvie Choblet , Josee Golay
- Applicant: Centre National de la Recherche Scientifique , Azienda Ospedaliera Papa Giovanni XXIII , Universite de Lausanne
- Applicant Address: FR Paris
- Assignee: Jean Kadouche,Centre National de la Recherche Scientifique,Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,University of Lausanne
- Current Assignee: Jean Kadouche,Centre National de la Recherche Scientifique,Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII,University of Lausanne
- Current Assignee Address: FR Paris; FR Paris; IT Bergamo; CH Lausanne
- Agency: Morgan, Lewis & Bockius LLP
- Priority: EP 305872 2011.07.07
- The original application number of the division: US14130773
- Main IPC: C07K16/18
- IPC: C07K16/18 ; C07K16/28 ; C07K16/46
Abstract:
The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
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