- Patent Title: Selective labeling of 5-methylcytosine in circulating cell-free DNA
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Application No.: US16645739Application Date: 2018-09-11
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Publication No.: US11946043B2Publication Date: 2024-04-02
- Inventor: Chunxiao Song , Paulina Siejka
- Applicant: Ludwig Institute for Cancer Research Ltd
- Applicant Address: CH Zurich
- Assignee: Ludwig Institute for Cancer Research Ltd
- Current Assignee: Ludwig Institute for Cancer Research Ltd
- Current Assignee Address: CH Zurich
- Agency: Fox Rothschild LLP
- International Application: PCT/US2018/050465 2018.09.11
- International Announcement: WO2019/051484A 2019.03.14
- Date entered country: 2020-03-09
- Main IPC: C12N15/10
- IPC: C12N15/10 ; C12Q1/6874
Abstract:
The present disclosure provides methods for selectively tagging 5-methylcytosine in a DNA sample and using this approach for genome-wide profiling of 5-methylcytosine in a low input DNA sample such as circulating cell-free DNA.
Public/Granted literature
- US20200224190A1 SELECTIVE LABELING OF 5-METHYLCYTOSINE IN CIRCULATING CELL-FREE DNA Public/Granted day:2020-07-16
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