Invention Grant
- Patent Title: tRNA/pre-miRNA compositions and use in treating cancer
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Application No.: US17056203Application Date: 2019-05-21
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Publication No.: US11946049B2Publication Date: 2024-04-02
- Inventor: Aiming Yu , Pui Yan Ho , Meijuan Tu , Joseph L. Jilek , Qianyu Zhang , Hannah E. Petrek
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Bozicevic, Field & Francis LLP
- Agent Brian E. Davy
- International Application: PCT/US2019/033232 2019.05.21
- International Announcement: WO2019/226603A 2019.11.28
- Date entered country: 2020-11-17
- Main IPC: C07H21/02
- IPC: C07H21/02 ; A61K45/06 ; A61K47/69 ; C07H21/04 ; C12N15/113
Abstract:
Provided are hybrid tRNA/pre-miRNA molecules, e.g., comprising a single tRNA and one, two or more pre-miRNA molecules, useful for the production and therapeutic delivery of an inserted RNA sequence, e.g., one or more miRNAs. Also provided are liposomes and nanoparticles that include the hybrid tRNA/pre-miRNA molecules. Methods of treating cancer by administration of the hybrid tRNA/pre-miRNA molecules are also provided.
Public/Granted literature
- US20210246446A1 tRNA/pre-miRNA Compositions and Use in Treating Cancer Public/Granted day:2021-08-12
Information query
