Invention Grant
- Patent Title: Long germline DH genes and long HCDR3 antibodies
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Application No.: US16165018Application Date: 2018-10-19
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Publication No.: US11946063B2Publication Date: 2024-04-02
- Inventor: Matthias Wabl , Werner Mueller , Peter Burrows , Gloria Esposito , Bao Duong
- Applicant: TRIANNI, INC.
- Applicant Address: US DE Wilmington
- Assignee: TRIANNI, INC.
- Current Assignee: TRIANNI, INC.
- Current Assignee Address: US DE Wilmington
- Agency: MEDLER FERRO WOODHOUSE & MILLS PLLC
- Priority: EP 198800 2017.10.27
- Main IPC: C12N15/85
- IPC: C12N15/85 ; A01K67/027 ; A01K67/0278 ; C07K16/18 ; C12N5/074 ; C12N15/10 ; C12N15/62 ; C40B40/10
Abstract:
The invention relates to a long DH (LDH) cassette comprising a recombinant DH construct comprising at least two DH gene segments encoding at least 10 amino acids of the HCDR3 amino acid sequence, wherein at least one of the DH gene segments is a heterologous DH gene segment; an immunoglobulin heavy chain locus and a transgenic non-human animal comprising the same; and their use in producing an immunoglobulin library with long HCDR3 regions.
Public/Granted literature
- US20190127757A1 LONG GERMLINE DH GENES AND LONG HCDR3 ANTIBODIES Public/Granted day:2019-05-02
Information query
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