Invention Grant
- Patent Title: Gene involved in synthesis of cyclic peptide compound, method for producing cyclic peptide compound using the same, and transformant comprising the same
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Application No.: US17549492Application Date: 2021-12-13
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Publication No.: US11946086B2Publication Date: 2024-04-02
- Inventor: Takashi Kubo , Masayuki Machida , Maiko Umemura , Keietsu Abe , Akira Yoshimi , Tomonori Fujioka , Shigenari Yamaguchi , Kiyoshi Kawai
- Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY , TOHOKU UNIVERSITY , KUMIAI CHEMICAL INDUSTRY CO., LTD.
- Applicant Address: JP Tokyo
- Assignee: TOHOKU UNIVERSITY,KUMIAI CHEMICAL INDUSTRY CO., LTD.
- Current Assignee: TOHOKU UNIVERSITY,KUMIAI CHEMICAL INDUSTRY CO., LTD.
- Current Assignee Address: JP Sendai; JP Tokyo
- Agency: Birch, Stewart, Kolasch & Birch, LLP
- Priority: JP 17000770 2017.01.05
- The original application number of the division: US16476000
- Main IPC: C12N9/10
- IPC: C12N9/10 ; C07K7/64 ; C12N15/80 ; C12P21/02 ; A61K38/10
Abstract:
This invention is intended to identify a gene cluster involved in biosynthesis of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species and to establish a system for synthesizing such cyclic peptide compound. The gene is composed of a first module to a tenth module and encodes a protein having activity of synthesizing a nonribosomal peptide constituting a basic peptide backbone of a cyclic peptide compound produced by a filamentous fungus of the Curvularia species.
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