Invention Grant
- Patent Title: Methods for measuring and improving CRISPR reagent function
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Application No.: US17357046Application Date: 2021-06-24
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Publication No.: US11946163B2Publication Date: 2024-04-02
- Inventor: Gregory V. Kryukov , Michael R. Schlabach , Jason J. Merkin
- Applicant: KSQ Therapeutics, Inc.
- Applicant Address: US MA Cambridge
- Assignee: KSQ Therapeutics, Inc.
- Current Assignee: KSQ Therapeutics, Inc.
- Current Assignee Address: US MA Lexington
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C40B30/04
- IPC: C40B30/04 ; C12N15/10 ; C12N15/11 ; C40B50/06 ; G16B20/00 ; G16B30/00
Abstract:
The invention describes a novel system for identifying optimized gRNAs for use in CRISPR/Cas9 genome editing platforms. The invention allows for the determination of specific gene alterations rendered by a particular gRNA, thereby permitting the generation of optimized gRNA libraries.
Public/Granted literature
- US20220010304A1 METHODS FOR MEASURING AND IMPROVING CRISPR REAGENT FUNCTION Public/Granted day:2022-01-13
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