Disclosed are a valve body connection structure and a valve assembly with the valve body connection structure. The valve body connection structure includes: a first connector including a first connection part and a first plug-in part, wherein the first connection part is fixedly connected to the main valve, and the first plug-in part is disposed on the first connection part; and a second connector including a second connection part, a second plug-in part and an extension part, wherein the second connection part is fixedly connected to the pilot valve, the second plug-in part is disposed on the second connection part, the first plug-in part matches the second plug-in part in an insertion manner, the extension part is disposed on the second connection part, and the extension part is provided with an assembly hole allowing a pipeline of the pilot valve to pass through.