Methods and systems are provided for accurately filling holes, regions, and/or portions of high-resolution images using guided upsampling during image inpainting. For instance, an image inpainting system can apply guided upsampling to an inpainted image result to enable generation of a high-resolution inpainting result from a lower-resolution image that has undergone inpainting. To allow for guided upsampling during image inpainting, one or more neural networks can be used. For instance, a low-resolution result neural network (e.g., comprised of an encoder and a decoder) and a high-resolution input neural network (e.g., comprised of an encoder and a decoder). The image inpainting system can use such networks to generate a high-resolution inpainting image result that fills the hole, region, and/or portion of the image.