Invention Grant
- Patent Title: Bioconjugates containing sulfamide linkers for use in treatment
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Application No.: US16076279Application Date: 2017-02-08
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Publication No.: US11951175B2Publication Date: 2024-04-09
- Inventor: Jorge Merijn Mathieu Verkade , Maria Antonia Wijdeven , Petrus Josephus Jacobus Maria Van De Sande , Remon Van Geel , Floris Louis Van Delft , Sander Sebastiaan Van Berkel
- Applicant: Synaffix B.V.
- Applicant Address: NL Oss
- Assignee: Synaffix B.V.
- Current Assignee: Synaffix B.V.
- Current Assignee Address: NL Oss
- Agency: Foley & Lardner LLP
- Priority: EP 154712 2016.02.08 EP 154739 2016.02.08 EP 173595 2016.06.08 EP 173599 2016.06.08
- International Application: PCT/EP2017/052788 2017.02.08
- International Announcement: WO2017/137456A 2017.08.17
- Date entered country: 2018-08-07
- Main IPC: A61K47/68
- IPC: A61K47/68 ; A61K47/54 ; A61K47/66 ; A61P35/00 ; C07K14/435
Abstract:
The present invention is based on the surprising finding that the linker employed in a bioconjugate, such as an anti-body-drug conjugate, is not therapeutically inert but has an effect on the therapeutic index of the bioconjugate. The present invention thus concerns a method for increasing the therapeutic index of a bioconjugate and the bioconjugates for use in treatment, in particular cancer. The bioconjugates according to the invention have a sulfamide linker comprising a group according to formula (1).
Public/Granted literature
- US20190262467A1 BIOCONJUGATES CONTAINING SULFAMIDE LINKERS FOR USE IN TREATMENT Public/Granted day:2019-08-29
Information query
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