Invention Grant
- Patent Title: Methods for treating subjects suffering from acute myeloid leukemia with FLT3 ligand-targeted miR-150 nanoparticles
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Application No.: US17375548Application Date: 2021-07-14
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Publication No.: US11951178B2Publication Date: 2024-04-09
- Inventor: Jianjun Chen , Seungpyo Hong , Xi Jiang , Zejuan Li
- Applicant: University of Cincinnati , The Board of Trustees of the University of Illinois , The University of Chicago
- Applicant Address: US OH Cincinnati
- Assignee: University of Cincinnati,University of Chicago,The Board of Trustees of the University of Illinois
- Current Assignee: University of Cincinnati,University of Chicago,The Board of Trustees of the University of Illinois
- Current Assignee Address: US OH Cincinnati; US IL Chicago; US IL Urbana
- Agency: Dinsmore & Shohl LLP
- The original application number of the division: US16310104
- Main IPC: C12N15/11
- IPC: C12N15/11 ; A61K31/551 ; A61K31/7105 ; A61K38/19 ; A61K45/06 ; A61K47/59 ; A61K47/62 ; A61K47/69 ; A61P35/02 ; C12N15/113
Abstract:
A nanoparticle delivery system designed for sustained delivery of microRNA-150 (miR-150) to FLT3-overexpressing acute myeloid leukemia (AML) cells, the delivery system comprising poly(amidoamine) (PAMAM) dendrimers complexed with miR-150, wherein at least one dendrimer is surface-functionalized with a ligand specific for FLT3 receptor, and methods for treating AML characterized by FLT3-overexpression are provided.
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