Invention Grant
- Patent Title: Stable liquid pharmaceutical preparation
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Application No.: US16310585Application Date: 2017-06-28
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Publication No.: US11951207B2Publication Date: 2024-04-09
- Inventor: Joon Won Lee , Won Yong Han , Su Jung Kim , Jun Seok Oh , So Young Kim , Su Hyeon Hong , Yeon Kyeong Shin
- Applicant: Celltrion Inc.
- Applicant Address: KR Incheon
- Assignee: Celltrion Inc.
- Current Assignee: Celltrion Inc.
- Current Assignee Address: KR Incheon
- Agency: Wood, Phillips, Katz, Clark & Mortimer
- Priority: KR 20160083039 2016.06.30
- International Application: PCT/KR2017/006855 2017.06.28
- International Announcement: WO2018/004260A 2018.01.04
- Date entered country: 2018-12-17
- Main IPC: A61K9/08
- IPC: A61K9/08 ; A61K39/00 ; A61K39/395 ; A61P37/02 ; A61P37/04 ; A61P37/06 ; C07K16/00 ; C07K16/24 ; A61K47/10 ; A61K47/18 ; A61K47/26

Abstract:
The present invention provides a stable liquid pharmaceutical formulation containing: an antibody or its antigen-binding fragment; a surfactant; a sugar or its derivative; and a buffer. The stable liquid pharmaceutical formulation according to the present invention has low viscosity while containing a high content of the antibody, has excellent long-term storage stability based on excellent stability under accelerated conditions and severe conditions, and may be administered subcutaneously.
Public/Granted literature
- US20210000743A1 STABLE LIQUID PHARMACEUTICAL PREPARATION Public/Granted day:2021-01-07
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