A system and method of stabilizing a vehicle are disclosed. In accordance with one aspect, a self-stabilizing vehicle having an articulated frame may generally comprise: a base frame portion coupled to one or more wheels; an operator frame portion to support an operator of the vehicle; a hinge assembly operably coupling the base frame portion and the operator frame portion; and a control unit to drive the hinge assembly causing the operator frame portion to rotate (relative to the base frame portion) about one or more hinge axes as a function of inertial data and speed data, and optionally steering control input signals. In some two-wheeled applications, both wheels are steerable; additionally, both wheels may be driven. Alternative vehicles are disclosed having one wheel and three wheels.