Invention Grant
- Patent Title: Nucleic acids encoding anti-TREM-1 antibodies
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Application No.: US17472051Application Date: 2021-09-10
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Publication No.: US11952420B2Publication Date: 2024-04-09
- Inventor: Achal Pashine , Michael L Gosselin , Aaron P. Yamniuk , Derek A. Holmes , Guodong Chen , Priyanka Apurva Madia , Richard Yu-Cheng Huang , Stephen Michael Carl
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agency: Morgan, Lewis & Bockius LLP
- The original application number of the division: US16371964 2019.04.01
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K47/68 ; A61P29/00 ; C12N15/13 ; C12N15/63 ; C12N15/85
Abstract:
Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
Public/Granted literature
- US20220002404A1 ANTI-TREM-1 ANTIBODIES AND USES THEREOF Public/Granted day:2022-01-06
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