Invention Grant
- Patent Title: Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137
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Application No.: US16769299Application Date: 2018-12-04
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Publication No.: US11952422B2Publication Date: 2024-04-09
- Inventor: Shun Shimizu , Shu Wen Samantha Ho , Naoka Hironiwa , Mika Sakurai , Taro Miyazaki , Tomoyuki Igawa
- Applicant: Chugai Seiyaku Kabushiki Kaisha
- Applicant Address: JP Tokyo
- Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee: Chugai Seiyaku Kabushiki Kaisha
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP 17233104 2017.12.05
- International Application: PCT/JP2018/044493 2018.12.04
- International Announcement: WO2019/111871A 2019.06.13
- Date entered country: 2020-06-03
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/30 ; C40B30/04
Abstract:
Antigen-binding domains that are capable of binding to CD3 and CD137 but do not bind to CD3 and CD137 at the same time and methods of using the same are provided. Methods to obtain antigen binding domains which bind to two or more different antigen more efficiently are also provided.
Public/Granted literature
- US20200377595A1 ANTIGEN-BINDING MOLECULE COMPRISING ALTERED ANTIBODY VARIABLE REGION BINDING CD3 AND CD137 Public/Granted day:2020-12-03
Information query
