Invention Grant
- Patent Title: Multivalent antibody
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Application No.: US16370346Application Date: 2019-03-29
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Publication No.: US11952424B2Publication Date: 2024-04-09
- Inventor: Cornelis Adriaan de Kruif , Linda Johanna Aleida Hendriks , Ton Logtenberg
- Applicant: MERUS N.V.
- Applicant Address: NL Utrecht
- Assignee: merus n.v.
- Current Assignee: merus n.v.
- Current Assignee Address: NL Utrecht
- Agency: STERNE, KESSLER, GOLDSTEIN & FOX P.L.L.C.
- Main IPC: C07K16/28
- IPC: C07K16/28

Abstract:
The invention relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains; and at least one additional binding domain, wherein the base antibody portion is connected by a linker to the at least one additional binding domain, wherein each binding domain of the base antibody portion and each of the at least one additional binding domains all have a common variable region, and wherein the linker comprises a hinge sequence or a sequence derived from a hinge sequence. The invention also relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains; and at least one additional binding domain, wherein at least one additional binding domain comprises a CH1 region and is connected to the base antibody portion by said linker, linking a variable region of the base antibody portion and the CH1 region, and wherein the multivalent antibody binds to at least three different epitopes.
Public/Granted literature
- US20190352401A1 MULTIVALENT ANTIBODY Public/Granted day:2019-11-21
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