- Patent Title: Generation of human pluripotent stem cell derived functional beta cells showing a glucose-dependent mitochondrial respiration and two-phase insulin secretion response
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Application No.: US16817413Application Date: 2020-03-12
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Publication No.: US11952591B2Publication Date: 2024-04-09
- Inventor: Sebastian Rieck , Alireza Rezania
- Applicant: Janssen Biotech, Inc.
- Applicant Address: US PA Horsham
- Assignee: Janssen Biotech, Inc.
- Current Assignee: Janssen Biotech, Inc.
- Current Assignee Address: US PA Horsham
- Agency: Klarquist Sparkman, LLP
- Agent Susan Alpert Siegel; Sheree Lynn Rybak
- Main IPC: C12N5/071
- IPC: C12N5/071 ; A61K35/39 ; C07K14/72 ; C12Q1/6806
Abstract:
The invention provides for methods of differentiating pancreatic endocrine cells into pancreatic beta cells expressing PDX1, NKX6.1, MAFA, UCN3 and SLC2A. These pancreatic beta cells may be obtained by step-wise differentiation of pluripotent stem cells. The pancreatic beta cells exhibit glucose-dependent mitochondrial respiration and glucose-stimulated insulin secretion similar to islet cells.
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