A door open and close mechanism for opening and closing a plurality of doors in a machine tool including a cover. The door open and close mechanism includes a linkage mechanism and a slide mechanism. The linkage mechanism is disposed between an operation door and an intermediate door. The linkage mechanism associates the intermediate door with the opening and closing of the operation door. The slide mechanism is disposed between the operation door and the linkage mechanism. The slide mechanism enables the operation door alone to open and close by a predetermined moving distance. When the operation door is operated to open and close within the moving distance, the operation door alone opens and closes by the slide mechanism. When the operation door is operated to open and close beyond the moving distance, the intermediate door opens and closes in association through the linkage mechanism.