A high-efficiency yield-increasing exploitation method for natural gas hydrates includes steps of drilling of natural gas hydrate reservoirs along horizontal wells, seepage increasing by fracturing for fracture forming and stability improvement by grouting in the natural gas hydrate reservoirs, and yield improvement by combined exploitation of depressurization of the horizontal wells and heat injection; according to the present invention, drilling time is shortened by rapid drilling along the horizontal wells, the permeability of the reservoirs can be effectively improved by fracturing for fracture forming, the stability of the reservoirs can be improved by injecting foam cement slurry into the reservoirs, and the yield of the natural gas hydrates can be improved by the combined exploitation method of depressurization of the horizontal wells and heat injection.