A variable holder module secures a variety of different expansion cards that may be installed within a computer or other information handling system. The holder module has a multi-sided component that is orientable according to which expansion card is to be secured within the computer. Each side of the component may thus correspond to a different one of the expansion cards. Once the expansion card is determined, a human or robotic picker need only orient component to the side that corresponds to the make/model of the expansion card. The holder module is thus adaptable to secure many different expansion cards that may be installed within the computer.