A portable remote medication management system for automated and adaptive precision dosing is disclosed. The system includes a medication delivery station comprising a receptacle that stores a pre-filled replaceable medication storage and closure container. The pre-filled medication container can store oral solid medication in storage silos above a rotary release mechanism and contains a storage and communication chip that communicates with the delivery station. The medication delivery station includes a delivery housing, a drive and control mechanism, communication interfaces with the container closure and remote devices, and a removable medication receptacle within the delivery station. The medication delivery station and medication closure container connect mechanically through a drive interface under the control of the station. Dosing parameter adjustments can be controlled by an administration portal and uploaded to the medication delivery station, as commanded by the administrator. Also disclosed are method operating the system and devices.