Methods and systems for mobile automation control of disease spread are disclosed. A computer-implemented method includes: determining, by a computing device, a health status of a person; determining, by the computing device, that the person is sick based on the health status; determining, by the computing device, facial and body movements of the person determined to be sick; determining, by the computing device, that the person determined to be sick performed a germ-transmitting activity based on the facial and body movements; and deploying, by the computing device, a cleaning robot to clean based on the determining that the person determined to be sick performed the germ-transmitting activity.