Methods and systems for allocating radio access network (RAN) spectrum resources among a plurality of mobile virtual network operators (MVNOs) of a network of base stations. The methods and systems include determining a slicing enforcement policy that assigns resource blocks (RBs) of frequency units and time slots of spectrum resources to each MVNO according to a slicing policy in which each MVNO is allocated an amount of the spectrum resources on at least one base station in a determined time span. The slicing enforcement policy minimizes overlap between each MVNO's set of RBs with another MVNO's set of RBs on a same base station, and interference between each MVNO's set of RBs with another MVNO's set of RBs on an interfering base station.