A patient transport apparatus transports a patient over a floor surface. The patient transport apparatus includes a support structure and a drive wheel assembly having at least one drive wheel, a powered drive system coupled to the at least one drive wheel, and at least two user input devices. The apparatus also includes a controller coupled to the powered drive system and user input devices configured to determine which one of the user input devices is active and operable to cause the powered drive system to rotate the drive wheel and to maintain the other user input device as inactive, or passive.